منابع مشابه
Apoptosis and carcinogenesis.
Many tumours are characterised by increased levels of apoptosis. This observation establishes significance for this process in tumour development, but it does little to elucidate the nature of this role, nor does it yield information relevant to the early stages of carcinogenesis. To gain a better understanding of the importance of apoptosis, it has been necessary to create a number of transgen...
متن کاملApoptosis in Carcinogenesis and Chemotherapy
A major challenge in the treatment of human breast cancer is the development of resistant mechaims to apoptosis in cancer cells that leads to a low senstivity to therapeutic agents. Recent advances in investigation of the cellular origin of breast cancer showed that breast cancers can be derived from a few tumor initiating cells or cancer stem cells. Increasing evidence supports the notion that...
متن کاملAberrant FHIT Expression Linkage to Bladder Carcinogenesis and Apoptosis
The bladder is a common site for cancer development in the urinary tract. Urinary bladder cancer ranks ninth in worldwide cancer incidence; it is the seventh most common malignancy in men and 17th in women. In the United States and Western Europe, the lifetime risk is about 1 in 25 and 1 in 80 for white males and females, respectively. Furthermore, approximately 145,000 patients die from this d...
متن کاملChanges of angiogenesis and tumor cell apoptosis during colorectal carcinogenesis.
Activation of the angiogenic process occurs during tumorigenesis, as does disturbance of cell proliferation and apoptosis. Seeking a potential correlation, we investigated tumor cell apoptosis, proliferation, and angiogenesis in the adenoma-carcinoma sequence of colorectal carcinogenesis using an in situ apoptosis detection kit and MIB-1 and anti-CD34 antibodies in 27 adenomas with low dysplasi...
متن کاملExpression of an inhibitor of apoptosis, survivin, in oral carcinogenesis.
A novel inhibitor of apoptosis, survivin, plays a role in oncogenesis. To determine the potential involvement of survivin in oral carcinogenesis, we investigated the distribution of survivin protein expression in oral squamous cell carcinomas (OSCCs) and oral pre-malignant lesions. The mRNA expression level and methylation status of the gene also were evaluated in OSCCs and OSCC-derived cell li...
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ژورنال
عنوان ژورنال: British Medical Bulletin
سال: 1997
ISSN: 0007-1420,1471-8391
DOI: 10.1093/oxfordjournals.bmb.a011630